Literature summary for 2.3.1.5 extracted from

Stepp, M.W.; Doll, M.A.; Carlisle, S.M.; States, J.C.; Hein, D.W.
Genetic and small molecule inhibition of arylamine N-acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231 (2018), Mol. Carcinog., 57, 549-558 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
(5E)-5-[(4-hydroxy-3,5-diiodophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one	25fold more selective towards the inhibition of recombinant human NAT1 than N-acetyltransferase 2. Incubation of MDA-MB-231 cell line with (5E)-5-[(4-hydroxy-3,5-diiodophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one results in 60% reduction in NAT1 activity and significant decreases in cell growth, anchorage-dependent growth, and anchorage-independent growth	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P18440	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MDA-MB-231 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
NAT1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	NAT1-specific shRNA reduces NAT1 activity in vitro by 39%, increases endogenous acetyl coenzyme A levels by 35%, and reduces anchorage-independent growth (7fold) without significant effects on cell morphology, growth rates, anchorage-dependent colony formation, or invasiveness. 12fold overexpression of NAT1 activity does not significantly affect anchorage-dependent cell growth, anchorage-independent cell growth, and relative invasiveness	Homo sapiens

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Release 2023.1 (January 2023)